Recombinant interleukin-2 infusions and serum IgG subclass levels.

Recombinant Interleukin-2 Infusions and Serum IgG Subclass Levels

Recombinant Interleukin-2 Infusions and Serum IgG Subclass Levels

Recombinant interleukin-2 infusions and decreased IgG2 subclass concentrations.

The administration of low doses of recombinant interleukin-2 (rIL-2) in vivo to patients with malignant neoplasms has been demonstrated to selectively increase the number of circulating natural killer (NK) cells in these patients. Recent evidence from SCID mouse models suggests that IgG subclass levels can be influenced by the presence and activity of NK cells. Therefore, we sought to examine t...

EVALUATION OF SERUM IgG SUBCLASS LEVELS IN ASTHMATIC AND ATOPIC CHILDREN WITH RECURRENT INFECTION

Serum IgG subclass levels were measured using an indirect immunoenzymatic assay (ELISA) with monoclonal antibodies in 16 children with asthma and 13 children with atopy who had mostly recurrent infections. Seven of the asthmatic children had marked low or low normal levels of IgG4, six had marked low or low normal levels of IgG 3, two had marked low normal levels of both IgG2, and IgG 3 and...

Serum interleukin-2 receptor and interferon-alpha levels in a patient with allergic granulomatous angiitis (Churg-Strauss).

A patient with allergic granulomatous angiitis accompanied by increases in serum interleukin-2 receptor (IL-2R) and interferon-alpha (IFN-alpha) levels is reported. Laboratory findings revealed leukocytosis with eosinophilia and increased serum IgE and IgG. The serum IL-2R and IFN-alpha were increased. The serum immune complex, interferon-beta, -gamma and complements remained at normal levels. ...